Chronic Copper Poisoning in Sheep

Chronic Copper Poisoning in Sheep: Liver Injury

Pathogenesis of liver injury in chronic copper poisoning of sheep was investigated using two experiments. Test sheep were dosed orally with a 0.2 % solution of CuSO4.5H2O at the rate of 10 ml/Kg body weight on five days of the week, until first day of the haemolytic crisis (HC). Liver samples were taken during the prehaemolytic period and on the first or second day of the HC, liver changes were...

Wilson's disease or chronic copper poisoning?

Walker-Smith, J. A., and Blomfield, J. (1973). Archives of Disease in Childhood, 48, 476. Wilson's disease or chronic copper poisoning? The case history is given of a child who presented at 14 months with ascites and was found to have severe micronodular cirrhosis with biochemical evidence of Wilson's disease, but in view of the severity of the pathology and early age of presentation, the possi...

Chronic copper poisoning presenting as pink disease.

held by loose connective tissue makes it mobile and, in children, the mucous membrane may have developed more strongly than the muscularis mucosae. They concluded that two factors might operate: first, a congenital weakness of tissue with an unduly wide urethra and, secondly, an acquired factor such as debility or inflammation. Other theories frequently mentioned are redundancy of the urethral ...

Attempted induction of chronic copper poisoning in boma confined impala.

Induction of chronic copper poisoning in ten boma-confined impala was attempted in a randomized, single dose, parallel designed, titration study using five increasing oral doses, ranging between 125 mg/kg to 1000 mg/kg, of copper oxide needles. Two untreated impala were kept as controls. Impala (n = 1) from each treatment group were culled 52 d and 105 d after treatment and examined for tissue ...

Copper Toxicity in Sheep